Super-resolution microscopy reveals distinct epigenetic states regulated by estrogen receptor activity
Tara K. Akhshi, Shengen Shawn Hu, Esmé Wheeler, Christian Hellriegel, Douglas S. Richardson, Nicole Cayting, Nicole A. Traphagen, Wangu Mvula, Buraq Ahmed, Rinath M. Jeselsohn, Chongzhi Zang, Myles A Brown
The paper uses super-resolution microscopy to show that estrogen receptor activity regulates distinct chromatin structures marked by H3K27ac, revealing dynamic epigenetic states and their implications for transcriptional activity and cancer resistance.
bioRxiv · Jun 16, 2025 · PreprintCancer Biology