Author

Buraq Ahmed

Dana-Farber Cancer InstituteORCID 0009-0001-4351-9510Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Esmé Wheeler· 2 shared Myles A BrowniD· 2 shared Nicole A. TraphageniD· 2 shared Tara K. AkhshiiD· 2 shared Alan D. D’AndreaiD· 1 shared Alok K. TewariiD· 1 shared Chongzhi ZangiD· 1 shared Christian AlfieriiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Esmé Wheeler

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2 papers

Recent·Most cited

Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewedJan 27, 2026

Lack of synergy between AR targeted therapies and PARP inhibitors in homologous recombination-proficient prostate cancer

Nicole A. Traphagen, Esmé Wheeler, Rong Li…·Myles A Brown

This study shows that AR inhibition does not enhance PARP inhibitor efficacy in HR-proficient prostate cancer and instead impairs response in castration-sensitive cells.

9 citationstop 1%

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintJun 16, 2025

Super-resolution microscopy reveals distinct epigenetic states regulated by estrogen receptor activity

Tara K. Akhshi, Shengen Shawn Hu, Esmé Wheeler…·Myles A Brown

The paper uses super-resolution microscopy to show that estrogen receptor activity regulates distinct chromatin structures marked by H3K27ac, revealing dynamic epigenetic states and their implications for transcriptional activity and cancer resistance.

DOI 10.1101/2025.06.16.659976

humanChIP-seq

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