Author

Esmé Wheeler

Dana-Farber Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Buraq AhmediD· 2 shared Myles A BrowniD· 2 shared Nicole A. TraphageniD· 2 shared Tara K. AkhshiiD· 2 shared Alan D. D’AndreaiD· 1 shared Alok K. TewariiD· 1 shared Chongzhi ZangiD· 1 shared Christian AlfieriiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Buraq AhmedORCID

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2 papers

Recent·Most cited

Lack of synergy between AR targeted therapies and PARP inhibitors in homologous recombination-proficient prostate cancer

Nicole A. Traphagen, Esmé Wheeler, Rong Li, Tara K. Akhshi, Ramya Ravindranathan, Christian Alfieri, Feng Lu, Buraq Ahmed, Alok K. Tewari, Steven P. Balk, Peter S. Nelson, Eva Corey, Henry Long, Alan D. D’Andrea, Xintao Qiu, Myles A Brown

This study shows that AR inhibition does not enhance PARP inhibitor efficacy in HR-proficient prostate cancer and instead impairs response in castration-sensitive cells.

Proceedings of the National Academy of Sciences · Jan 27, 2026Peer-reviewedCancer Biology

Super-resolution microscopy reveals distinct epigenetic states regulated by estrogen receptor activity

Tara K. Akhshi, Shengen Shawn Hu, Esmé Wheeler, Christian Hellriegel, Douglas S. Richardson, Nicole Cayting, Nicole A. Traphagen, Wangu Mvula, Buraq Ahmed, Rinath M. Jeselsohn, Chongzhi Zang, Myles A Brown

The paper uses super-resolution microscopy to show that estrogen receptor activity regulates distinct chromatin structures marked by H3K27ac, revealing dynamic epigenetic states and their implications for transcriptional activity and cancer resistance.

bioRxiv · Jun 16, 2025 · PreprintCancer Biology