Author

Tara K. Akhshi

Harvard UniversityORCID 0000-0002-4575-4442Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Myles A BrowniD· 3 shared Nicole A. TraphageniD· 3 shared Buraq AhmediD· 2 shared Esmé Wheeler· 2 shared Rinath M. JeselsohniD· 2 shared Alan D. D’AndreaiD· 1 shared Alok K. TewariiD· 1 shared Amy Grayson· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

Myles A BrownORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Circadian misalignment underlies immune escape in breast cancer

Chuqian Liang, Zunpeng Liu, Xiaoke Xu, Zhen Xu, Qi Zhang, Tao Zhang, Riley J. Mangan, Bingqiu Xiu, Gongwei Wu, Tara K. Akhshi, Zachary M. Sandusky, G. Kenneth Gray, Na Zhang, Genevra M. Kuziel, Nicole A. Traphagen, , Myles Brown

The paper identifies circadian misalignment between cancer and immune cells in breast tumors as a mechanism of immune evasion and therapeutic resistance.

bioRxiv · May 29, 2026 · PreprintCancer Biology

Lack of synergy between AR targeted therapies and PARP inhibitors in homologous recombination-proficient prostate cancer

Nicole A. Traphagen, Esmé Wheeler, Rong Li, Tara K. Akhshi, Ramya Ravindranathan, Christian Alfieri, Feng Lu, Buraq Ahmed, Alok K. Tewari, Steven P. Balk, Peter S. Nelson, Eva Corey, Henry Long, Alan D. D’Andrea, Xintao Qiu, Myles A Brown

This study shows that AR inhibition does not enhance PARP inhibitor efficacy in HR-proficient prostate cancer and instead impairs response in castration-sensitive cells.

Proceedings of the National Academy of Sciences · Jan 27, 2026Peer-reviewedCancer Biology

Super-resolution microscopy reveals distinct epigenetic states regulated by estrogen receptor activity

Tara K. Akhshi, Shengen Shawn Hu, Esmé Wheeler, Christian Hellriegel, Douglas S. Richardson, Nicole Cayting, Nicole A. Traphagen, Wangu Mvula, Buraq Ahmed, Rinath M. Jeselsohn, Chongzhi Zang, Myles A Brown

The paper uses super-resolution microscopy to show that estrogen receptor activity regulates distinct chromatin structures marked by H3K27ac, revealing dynamic epigenetic states and their implications for transcriptional activity and cancer resistance.

bioRxiv · Jun 16, 2025 · PreprintCancer Biology