Rinath M. Jeselsohn

This study shows HER2 mutations drive HER2/HER3 hyperactivation in ILC, making it sensitive to HER2/HER3-targeting ADCs, and highlights the synergy between T-DXd and P-DXd.

The paper identifies circadian misalignment between cancer and immune cells in breast tumors as a mechanism of immune evasion and therapeutic resistance.

The paper uses super-resolution microscopy to show that estrogen receptor activity regulates distinct chromatin structures marked by H3K27ac, revealing dynamic epigenetic states and their implications for transcriptional activity and cancer resistance.

This study identifies an estrogen receptor signaling program in HR+ breast cancer that suppresses immune responses by reducing T cell infiltration and HLA expression, suggesting therapeutic targets to enhance immunogenicity.

This study quantifies cell proliferation in tumors using multiplexed imaging and identifies spatial and temporal patterns of cell cycle regulation.

CoBRA provides a reproducible pipeline for ChIP/ATAC-seq analysis, including peak calling, clustering, and pathway analysis, with code available at the given URL.