Craters on the melanoma surface facilitate tumor-immune interactions and demonstrate pathologic response to checkpoint blockade in humans
Aya Ludin, Georgia L. Stirtz, Asaf Tal, Ajit J. Nirmal, Kathleen Lindahl Pfaff, Michael P. Manos, Naomi R. Besson, Nebiyat Eskndir, Billie A. Porter, Stephanie M. Jones, Hannah Mae Faulkner, Qiyu Gong, Sophia Liu, Irving Barrera, Lijian Wu, , Leonard Ira Zon
The paper identifies crater-shaped structures in melanoma that enhance immune response to checkpoint blockade therapy in humans and zebrafish.
Cell · Oct 17, 2025Peer-reviewedCancer Biology