An evolutionarily acquired microRNA shapes development of mammalian cortical projections
Jessica Diaz, Verl B. Siththanandan, Victoria Lu, Nicole Gonzalez-Nava, Lincoln W. Pasquina, Jessica L. MacDonald, Mollie B. Woodworth, Abdulkadir Özkan, Ramesh V. Nair, Zihuai He, Vibhu Sahni, Peter Sarnow, Theo D. Palmer, Jeffrey D. Macklis, Suzanne A. Tharin
The paper identifies a microRNA cluster unique to placental mammals that promotes corticospinal neuron identity by repressing LMO4, a callosal gene, thereby contributing to neuronal subtype diversity in the mammalian brain.
Proceedings of the National Academy of Sciences · Nov 2, 2020Peer-reviewedNeuroscience