Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
Joseph Longo, Lisa M. DeCamp, Brandon M. Oswald, Robert Teis, Alfredo Reyes-Oliveras, Michael S. Dahabieh, Abigail E. Ellis, Michael P. Vincent, Hannah N. Damico, Kristin L. Gallik, Nicole M Foy, Shelby E. Compton, Colt D. Capan, Kelsey S. Williams, Corinne R. Esquibel, , Russell G. Jones
This study identifies glucose-dependent glycosphingolipid biosynthesis as essential for CD8+ T cell expansion and tumor control, independent of energy production.
Cell Metabolism · Aug 5, 2025Peer-reviewedImmunology