Author

Michael S. Dahabieh

Van Andel InstituteORCID 0000-0002-2518-7129Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Abigail E. EllisiD· 4 shared Lisa M. DeCampiD· 4 shared Russell G. JonesiD· 4 shared Ryan D. SheldoniD· 4 shared Brandon M. OswaldiD· 3 shared Connie M. KrawczykiD· 3 shared Joseph LongoiD· 3 shared Kelsey S. WilliamsiD· 3 shared

Activity by Year

2023-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersImmunology

Abigail E. EllisORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dietary Restriction Enhances CD8+ T Cell Ketolysis to Limit Exhaustion and Boost Anti-Tumor Immunity

Brandon M. Oswald, Lisa M. DeCamp, Joseph Longo, Michael S. Dahabieh, Nicholas Bunda, Benjamin K. Johnson, McLane J. Watson, Shixin Ma, Samuel E.J. Preston, Ryan D. Sheldon, Michael P. Vincent, Abigail E. Ellis, Molly T. Soper-Hopper, Christine N. Isaguirre, Dahlya Kamarudin, , Russell G. Jones

This study shows dietary restriction enhances CD8+ T cell ketolysis, improving mitochondrial function and anti-tumor immunity by reducing exhaustion.

Nature Metabolism · Dec 9, 2025Peer-reviewedImmunology

Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control

Joseph Longo, Lisa M. DeCamp, Brandon M. Oswald, Robert Teis, Alfredo Reyes-Oliveras, Michael S. Dahabieh, Abigail E. Ellis, Michael P. Vincent, Hannah N. Damico, Kristin L. Gallik, Nicole M Foy, Shelby E. Compton, Colt D. Capan, Kelsey S. Williams, Corinne R. Esquibel, , Russell G. Jones

This study identifies glucose-dependent glycosphingolipid biosynthesis as essential for CD8+ T cell expansion and tumor control, independent of energy production.

Cell Metabolism · Aug 5, 2025Peer-reviewedImmunology

NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion

Michael S. Dahabieh, Lisa M. DeCamp, Brandon M. Oswald, Susan M. Kitchen-Goosen, Zhen Fang Fu, Matthew Vos, Shelby E. Compton, Joseph Longo, Nicole M Foy, Kelsey S. Williams, Abigail E. Ellis, Amy Jo Johnson, Ibukunoluwa Sodiya, Michael Vincent, Hyoungjoo Lee, , Russell G. Jones

This study identifies the KEAP1-NRF2 pathway as a driver of CD8 T cell exhaustion by regulating the prostacyclin receptor PTGIR.

Nature Immunology · Jun 27, 2025Peer-reviewedImmunology

Combined single-sample metabolomics and RNAseq reveals a hepatic pyrimidine metabolic response to acute viral infection

Zachary Madaj, Michael S. Dahabieh, Vijayvardhan Kamalumpundi, Brejnev Muhizi Muhire, Dean Pettinga, Rebecca A. Siwicki, Abigail E. Ellis, Christine N. Isaguirre, Martha L. Escobar Galvis, Lisa M. DeCamp, Russell G. Jones, Scott A. Givan, Marie Adams, Ryan D. Sheldon

This study integrates metabolomics and RNAseq from the same liver samples to show that prior metabolite extraction does not harm RNAseq quality and reveals pyrimidine metabolism as a key pathway in acute viral infection.

RNA Biology · Apr 24, 2023Peer-reviewedMolecular Biology