Lisa M. DeCamp

Midbrain Tet1 dosage defines inter-individual binge-eating susceptibility

This study shows that Tet1 dosage in midbrain neurons determines binge-eating susceptibility in mice and links Tet1 methylation to human binge-eating behavior.

Dietary Restriction Enhances CD8+ T Cell Ketolysis to Limit Exhaustion and Boost Anti-Tumor Immunity

This study shows dietary restriction enhances CD8+ T cell ketolysis, improving mitochondrial function and anti-tumor immunity by reducing exhaustion.

Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control

This study identifies glucose-dependent glycosphingolipid biosynthesis as essential for CD8+ T cell expansion and tumor control, independent of energy production.

NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion

This study identifies the KEAP1-NRF2 pathway as a driver of CD8 T cell exhaustion by regulating the prostacyclin receptor PTGIR.

Combined single-sample metabolomics and RNAseq reveals a hepatic pyrimidine metabolic response to acute viral infection

This study integrates metabolomics and RNAseq from the same liver samples to show that prior metabolite extraction does not harm RNAseq quality and reveals pyrimidine metabolism as a key pathway in acute viral infection.

In vivo metabolite tracing of T cells

This paper describes a protocol to study T cell metabolism in vivo using isotopically labeled metabolites and mass spectrometry.