Connie M. Krawczyk

Dietary Restriction Enhances CD8+ T Cell Ketolysis to Limit Exhaustion and Boost Anti-Tumor Immunity

This study shows dietary restriction enhances CD8+ T cell ketolysis, improving mitochondrial function and anti-tumor immunity by reducing exhaustion.

Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control

This study identifies glucose-dependent glycosphingolipid biosynthesis as essential for CD8+ T cell expansion and tumor control, independent of energy production.

NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion

This study identifies the KEAP1-NRF2 pathway as a driver of CD8 T cell exhaustion by regulating the prostacyclin receptor PTGIR.

Trained Immunity Affecting Dendritic Cell Differentiation and Function in Rheumatoid Arthritis

This study shows that trained immunity affects dendritic cell differentiation and function in rheumatoid arthritis, altering their gene expression and immune responses.

A noncanonical polyamine from bacteria antagonizes animal mitochondrial function

This study identifies N1-APA, a noncanonical polyamine produced by bacteria, as a bioactive metabolite that antagonizes animal mitochondrial function and macrophage activation.

DNA Methylation Dynamics and Dysregulation Delineated by High-Throughput Profiling in the Mouse

This paper develops a high-throughput DNA methylation array and atlas for mice, revealing tissue-specific methylation patterns and their associations with aging, differentiation, and disease.