The ENL-USP7 Complex Regulates HIV Latency Through BRD4 Stabilization
Waqas Ahmed, Xiaoyi Li, Ciniso Sylvester Shabangu, Hongjie Chen, Nikesh Kutwal, Jennifer Kirchherr, Wenshe Ray Liu, Xin Li, Yongcheng Song, Kaixiu Luo, H. Ümit Kanıskan, Jian Jin, Sara Gianella, David M. Margolis, Nancie M. Archin, , Guochun Jiang
This paper identifies the ENL-USP7 complex as a host factor that stabilizes BRD4 to maintain HIV-1 latency and shows that disrupting this complex reactivates latent HIV.
bioRxiv · Apr 9, 2026 · PreprintMicrobiology