Sara Gianella

Deconvolution of HIV-1 Mutational Signatures Reveals Dominant and Donor-Specific APOBEC3-Associated Mutagenesis Across Anatomical Compartments

The paper deconvolves HIV-1 mutational signatures across anatomical compartments and identifies APOBEC3-associated mutagenesis as a major contributor, showing donor-specific patterns.

SPP1+ Microglia Are Associated with Neuroimmune Rewiring and Glutamatergic Neuronal Injury in ART-Suppressed People Living with HIV

In ART-suppressed human brain, an SPP1+ activated microglial subset holds most detected HIV RNA and shows chronic interferon-I and MHC-I signatures, alongside complement signaling and neuronal loss.

The ENL-USP7 Complex Regulates HIV Latency Through BRD4 Stabilization

This paper identifies the ENL-USP7 complex as a host factor that stabilizes BRD4 to maintain HIV-1 latency and shows that disrupting this complex reactivates latent HIV.

Cell-type specific impact of opioid use disorder and HIV on the human forebrain and cerebellum

This study examines the cell-type specific effects of opioid use disorder and HIV on the human brain, identifying changes in gene regulation, metabolism, and immune responses across different brain regions.

Cytokine and Chemokine Receptor Profiles in Adipose Tissue Vasculature Unravel Endothelial Cell Responses in HIV

This study examines cytokine and chemokine receptor expression in adipose tissue endothelial cells of HIV-positive individuals, identifying receptor differences and their potential role in vascular dysfunction.