Guochun Jiang

This study identifies an HIV-1 Tat variant (R52W) that reduces transcriptional activity, potentially contributing to viral persistence during ART.

In ART-suppressed human brain, an SPP1+ activated microglial subset holds most detected HIV RNA and shows chronic interferon-I and MHC-I signatures, alongside complement signaling and neuronal loss.

This paper develops a label-free diagnostic platform for HIV detection with smartphone integration, achieving attomolar sensitivity without sample pre-treatment.

This paper identifies the ENL-USP7 complex as a host factor that stabilizes BRD4 to maintain HIV-1 latency and shows that disrupting this complex reactivates latent HIV.

The paper identifies a microglia-specific promoter of the human HexB gene that can be used for AAV gene therapy targeting microglia in the CNS.