Author

Ciniso Sylvester Shabangu

University of North Carolina at Chapel HillORCID 0000-0001-5954-4254Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

David M. MargolisiD· 2 shared Guochun JiangiD· 2 shared Sara GianellaiD· 2 shared Yuyang Tang· 2 shared Antoine ChailloniD· 1 shared Edward P. BrowneiD· 1 shared H. Ümit KanıskaniD· 1 shared Hongjie Chen· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

David M. MargolisORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 10, 2026

✦ In-depth digest

SPP1+ Microglia Are Associated with Neuroimmune Rewiring and Glutamatergic Neuronal Injury in ART-Suppressed People Living with HIV

Ciniso Sylvester Shabangu, Hongjie Chen, Manickam Ashokkumar…·Guochun Jiang

In ART-suppressed human brain, an SPP1+ activated microglial subset holds most detected HIV RNA and shows chronic interferon-I and MHC-I signatures, alongside complement signaling and neuronal loss.

DOI 10.64898/2026.09.04.749241

humanscRNA-seq

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MicrobiologybioRxivPreprintApr 9, 2026

The ENL-USP7 Complex Regulates HIV Latency Through BRD4 Stabilization

Waqas Ahmed, Xiaoyi Li, Ciniso Sylvester Shabangu…·Guochun Jiang

This paper identifies the ENL-USP7 complex as a host factor that stabilizes BRD4 to maintain HIV-1 latency and shows that disrupting this complex reactivates latent HIV.

3 citations

humanexperimental assay

𝕏 PostBluesky