ndufs2-/- zebrafish have impaired survival, neuromuscular activity, morphology, and one-carbon metabolism treatable with folic acid
Dana Venditti Mitchell, Donna M. Iadarola, Neal D. Mathew, Kelsey Keith, Christoph Seiler, Sanghyeon Yu, Man Soo Kim, Niki Woodard, Vernon E. Anderson, Eiko Nakamaru‐Ogiso, Deanne M. Taylor, Marni J. Falk
This study generates ndufs2-/- zebrafish with CI deficiency, showing metabolic and neuromuscular defects treatable by folic acid.
bioRxiv · Jul 16, 2025 · PreprintPharmacology & Toxicology