Author

Donna M. Iadarola

Children's Hospital of PhiladelphiaORCID 0000-0003-1243-7245Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Kelsey KeithiD· 3 shared Marni J. FalkiD· 3 shared Cristina RemeşiD· 2 shared Eiko Nakamaru‐OgisoiD· 2 shared Neal D. MathewiD· 2 shared Vernon E. AndersoniD· 2 shared Agustin B. Velasco· 1 shared Christoph SeileriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersGenetics

Kelsey KeithORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintJul 24, 2026

Targeted modulation of IGFBP5/IGF1, THPO, and P38 MAPK signaling are potent therapeutic strategies generalizable for mitochondrial respiratory chain disease and osteosarcoma

Kelsey Keith, Min Peng, Cristina Remeş…·Marni J. Falk

The paper identifies THPO, IGF1, and MAPK as therapeutic targets for mitochondrial respiratory chain disease and osteosarcoma, showing their modulation can replicate the benefits of CHX treatment.

DOI 10.64898/2026.07.20.739625

humanC. elegans

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PhysiologybioRxivPreprintFeb 5, 2026

Cognate amino acid therapies provide preclinical benefit in 19 C. elegans models of ARS2 deficiency

Cristina Remeş, Kelsey Keith, Rui Xiao…·Marni J. Falk

This study shows that cognate amino acid treatment improves growth, neuromuscular function, and reduces stress in 19 C. elegans models of mt-ARS deficiency.

DOI 10.64898/2026.02.03.703549

C. elegansexperimental assay

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Pharmacology & ToxicologybioRxivPreprintJul 16, 2025

ndufs2-/- zebrafish have impaired survival, neuromuscular activity, morphology, and one-carbon metabolism treatable with folic acid

Dana Venditti Mitchell, Donna M. Iadarola, Neal D. Mathew…·Marni J. Falk

This study generates ndufs2-/- zebrafish with CI deficiency, showing metabolic and neuromuscular defects treatable by folic acid.

4 citations

zebrafishbulk RNA-seq

𝕏 PostBluesky