Targeting CHEK2-YBX1&YBX3 regulatory hub to potentiate immune checkpoint blockade response in gliomas
Heba A. Ali, Ningjia Zhou, Li Chen, Levi van Hijfte, Vivekanudeep Karri, Yalu Zhou, Karl John Habashy, Victor Andrés Arrieta, Kwang‐Soo Kim, Joseph T. Duffy, Ragini Yeeravalli, Deanna Marie Tiek, Xiao Mei Song, Snehasis Mishra, Catalina Lee-Chang, , Crismita Dmello
This study identifies the CHK2-YBX1&YBX3 hub as an immunosuppressive mechanism in gliomas and shows that targeting it with SU056 enhances immune checkpoint blockade efficacy.
bioRxiv · Mar 9, 2025 · PreprintCancer Biology