Author

Karl John Habashy

Northwestern UniversityORCID 0000-0003-1210-378XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Adam M. SonabendiD· 3 shared Victor Andrés ArrietaiD· 3 shared Catalina Lee-ChangiD· 2 shared Crismita DmelloiD· 2 shared Dieter Henrik HeilandiD· 2 shared Li Chen· 2 shared Aishi Zhao· 1 shared Akane YamamichiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

Adam M. SonabendORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintAug 19, 2026

Ultrasound-mediated blood-brain barrier modulation enhances T-cell access but requires immune activation for effective CNS immunity

Marco Gallus, Akane Yamamichi, Victor Andrés Arrieta…·Hideho Okada

This study shows that ultrasound-mediated BBB modulation alone does not generate effective CNS immunity, but combining it with systemic immune activation enhances T-cell responses and improves immunotherapy efficacy.

DOI 10.64898/2026.08.14.744698

mouseexperimental assay

𝕏 PostBluesky

Cancer BiologyNature CommunicationsPeer-reviewedJun 25, 2026

MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, enhances tumor-microglia crosstalk, and drives immune checkpoint blockade efficacy.

Kwang‐Soo Kim, Junyi Zhang, Victor Andrés Arrieta…·Adam M. Sonabend

This study identifies the MAPK/ERK pathway as a key regulator of glioma susceptibility to immune checkpoint blockade, showing it modulates interferon responses, T cell recruitment, and tumor-microglia interactions.

8 citationstop 1%

mousescRNA-seq

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Cancer BiologybioRxivPreprintMar 9, 2025

Targeting CHEK2-YBX1&YBX3 regulatory hub to potentiate immune checkpoint blockade response in gliomas

Heba A. Ali, Ningjia Zhou, Li Chen…·Crismita Dmello

This study identifies the CHK2-YBX1&YBX3 hub as an immunosuppressive mechanism in gliomas and shows that targeting it with SU056 enhances immune checkpoint blockade efficacy.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky