NGN2 Expression and Regional Patterning Allow Rapid Differentiation from hiPSCs to DRG-Like Neurons Responsive to Type 2 Cytokines
Carina Habich, Loan N. Miller, Nivea Granillo Luz, Laraib Iqbal Malik, Kavya Chegireddy, Mohammad Mehdi Maneshi, Michael Wolf, Markus P. Kummer, Hisato Iriki, Julian Röwe, Samuele G. Marro, Victoria Scott, Kathleen M. Smith, Brian Kim, Peter Reinhardt, Eric R. Goedken
This study generates DRG-like neurons from hiPSCs using NGN2 overexpression and patterning factors, which respond to type 2 cytokines involved in itch.
bioRxiv · Aug 27, 2025 · PreprintNeuroscience