MIF-mediated reprogramming of myeloid lineage within the glioma tumor microenvironment impacts the efficacy of immune stimulatory gene therapy
Ziwen Zhu, Noah C Kanis, Anthony E George, Michael J. Albdewi, Yingxiang Li, Anzar Mujeeb, Brandon L. McClellan, Gurveer Singh, Jialin Liu, Wajd N. Al‐Holou, Jason A. Heth, Joshua D. Welch, Justin Durla Lathia, Pedro Ricardo Lowenstein, Richard Bucala, Maria Graciela Castro
This study identifies MIF-CD74 axis regulation of myeloid cells in gliomas and shows that MIF inhibition enhances immune therapy efficacy in wtIDH1 gliomas.
bioRxiv · Jan 14, 2026 · PreprintCancer Biology