Ziwen Zhu

Reprogramming the Immune Suppressive Tumor Microenvironment in Glioma Enhances the Efficacy of Immune-Mediated Gene Therapy

This study shows that combining CD73 inhibition with immune-stimulatory gene therapy improves treatment efficacy for wtIDH1 gliomas.

MIF-mediated reprogramming of myeloid lineage within the glioma tumor microenvironment impacts the efficacy of immune stimulatory gene therapy

This study identifies MIF-CD74 axis regulation of myeloid cells in gliomas and shows that MIF inhibition enhances immune therapy efficacy in wtIDH1 gliomas.

Epigenetic reprogramming of autophagy leads to uncovering a novel therapeutic target for mutant IDH1 astrocytomas

This study identifies autophagy as a critical survival pathway in mIDH1 gliomas and shows that inhibiting autophagy enhances radiosensitivity and tumor regression in preclinical models.