Jason A. Heth

This study uses patient-derived organoids to test drug responses in breast cancer brain metastases, showing subtype-specific variations and the potential of PI3K inhibitors regardless of PIK3CA mutation status.

This study identifies MIF-CD74 axis regulation of myeloid cells in gliomas and shows that MIF inhibition enhances immune therapy efficacy in wtIDH1 gliomas.

The paper identifies 3D topological defects and quasi-long-range order in glioma tumors, linking them to tumor aggression and cell density regulation.