Cancer BiologybioRxivPreprint
The Th1/Th17 axis regulates chimeric antigen receptor (CAR) T cell therapy toxicities
Payal Goala, Yongliang Zhang, Nolan Beatty…·Marco L. Davila
This study identifies a Th1/Th17 imbalance driven by IFN{gamma} that causes cytokine release syndrome and neutropenia in CAR-T therapy, suggesting IFN{gamma} blockade as a potential treatment.