TDP-43 self-assembly is regulated by its disordered NLS-region
Saskia Hutten, Emre Pekbilir, Benjamin M. R. Bourgeois, Xiaofei Ping, Christof Rickert, Nele S. Kuhr, Nora Knabe, Simone Mosna, Tobias Madl, Lukas S. Stelzl, Dorothee Dormann
This study shows that the disordered NLS-region of TDP-43 is essential for its self-assembly across multiple scales, with a minimal mutation preserving condensation while others reduce it.
bioRxiv · Jun 9, 2026 · PreprintBiochemistry