Lukas S. Stelzl

Kinase-phosphatase cycles drive self-sustained oscillations of protein condensates

This study shows that kinase-phosphatase cycles drive self-sustained oscillations in TDP-43 condensates through differential recruitment and slow redistribution of enzymes.

Multi-Domain Interplay Controls Full-Length TDP-43 Phase Separation and Condensate Dynamics

This study shows how different domains of TDP-43 interact to control phase separation and condensate dynamics through simulations and experiments.

Programmable DNA Protonuclei Reveal Environmental Context on Protein Phase Separation

This paper introduces programmable DNA-based protonuclei to study protein phase separation, showing that environmental factors significantly influence FUS behavior.

Phase separation behavior of TDP-43 governs its protein interactome and regulation of alternative splicing

This study investigates how TDP-43 phase separation affects its protein interactome and regulation of alternative splicing, showing PS-dependent interactions with RNA regulators.

A Phosphorylation-Induced Micellization switch in the low complexity domain of TDP-43

This study shows phosphorylation of TDP-43's low-complexity domain shifts its self-assembly from macrophase separation to micellization, potentially protecting against pathological aggregation.

Active Learning-Guided Peptide Design for Modulating Condensate Properties upon Recruitment

The paper uses active learning to design peptides that modulate the physical properties of a biomolecular condensate by interacting with MUT-16.

TDP-43 self-assembly is regulated by its disordered NLS-region

This study shows that the disordered NLS-region of TDP-43 is essential for its self-assembly across multiple scales, with a minimal mutation preserving condensation while others reduce it.

Atomistic simulations reveal sub-μs contact dynamics in MUT-16 condensates.

The paper uses atomistic simulations to study contact dynamics in MUT-16 condensates, finding short-lived contacts and identifying key interactions and factors influencing condensate behavior.

Proteolytic Control of an Auto-inhibitory Intrinsically Disordered Region Governs Small RNA Selectivity in Argonaute Proteins

The paper identifies a novel regulatory mechanism involving proteolytic processing of N-terminal intrinsically disordered regions in C. elegans Argonaute proteins, which controls small RNA selectivity and activity.

Multi-scale Simulations of MUT-16 Scaffold Protein Phase Separation and Client Recognition

This study uses multiscale simulations to investigate MUT-16 phase separation and its role in recruiting MUT-8, confirming key interactions through in vitro experiments.

Bidirectional control of a metabolic transition by the GID ubiquitin ligase

This study identifies Gid11 as a substrate receptor for the GID ubiquitin ligase in budding yeast, revealing its role in regulating metabolic transitions by targeting glycolytic factors during ethanol metabolism.

Molecular simulations of enzymatic phosphorylation of disordered proteins and their condensates

The paper uses molecular simulations to study how phosphorylation by CK1δ affects TDP-43 condensates and aggregation, finding that phosphorylation patterns depend on sequence and charge rather than position.

Biochemical communication with noisy feedback under energy constraints

This paper develops a framework for analyzing information transmission in biochemical reaction networks under energy constraints and derives bounds for reliable communication.

An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori

This study identifies a novel interaction between BmGtsf1L and BmVreteno's eTudor domain that facilitates piRNA biogenesis in Bombyx mori by connecting piRNA-loaded BmAgo3 and Gtsf1L.