Tobias Madl

A metabolic perspective on eIF1A and eIF3B inhibition as a potential therapeutic strategy in psoriasis

This study investigates the metabolic effects of eIF1A and eIF3B inhibition in psoriasis models, finding context-dependent metabolic changes and therapeutic benefits.

A histidine switch controls the pH-responsive self-assembly of a helical protein filament

The paper identifies a histidine switch that regulates pH-responsive self-assembly of a helical protein filament through electrostatic interactions.

TDP-43 self-assembly is regulated by its disordered NLS-region

This study shows that the disordered NLS-region of TDP-43 is essential for its self-assembly across multiple scales, with a minimal mutation preserving condensation while others reduce it.

Proteome-wide identification and modeling of interactions between transactivation domains and arginine-glycine-rich regions

The paper identifies and models interactions between transactivation domains and arginine-glycine-rich regions using proteome-scale data and simulations, revealing electrostatic mechanisms driving TF-RBP coupling.

The sequence context of RG/RGG motifs determines condensate formation, transportin-1 binding and chaperoning

The paper investigates how sequence context of RG/RGG motifs influences condensate formation, transportin-1 binding, and chaperoning using bioinformatics and experimental analysis.

Presenilin-1 controls glucose metabolism and identity of pancreatic beta cells

This study shows presenilin-1 regulates glucose metabolism and beta cell identity by controlling calcium homeostasis in pancreatic islets.

Methanobrevibacter smithii associates with colorectal cancer through trophic control of the cancer bacteriome

This study identifies Methanobrevibacter smithii as associated with colorectal cancer through trophic interactions with CRC-causing bacteria and archaeal-derived compounds.

A histidine switch regulates pH-dependent filament formation by the caspase-9 CARD

This study identifies a histidine switch in C9CARD that regulates pH-dependent filament formation through electrostatic interactions and structural changes.

Expanding the cultivable human archaeome: Methanobrevibacter intestini sp. nov. and strain Methanobrevibacter smithii GRAZ-2 from human feces

The paper isolates and characterizes two new Methanobrevibacter species from human feces, highlighting genomic and phenotypic differences.

Computational metabolic modeling unveils gut microbiomes role in metabolic shifts during murine cancer cachexia

This study identifies cachexia-associated microbial metabolites using computational modeling and metabolomic analyses in a murine cancer model.

Global analysis of protein arginine methylation

The paper develops an NMR-based method to quantify global protein arginine methylation levels across various biological samples and demonstrates its prevalence and modulation in health and disease.