Author
Johannes Gutenberg University MainzORCID 0000-0003-4093-9154Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Rodrigo F. Dillenburg, Lopatina Anastasia, Hao Ruan…·Edward A. Lemke
This study shows phosphorylation of TDP-43's low-complexity domain shifts its self-assembly from macrophase separation to micellization, potentially protecting against pathological aggregation.
Saskia Hutten, Emre Pekbilir, Benjamin M. R. Bourgeois…·Dorothee Dormann
This study shows that the disordered NLS-region of TDP-43 is essential for its self-assembly across multiple scales, with a minimal mutation preserving condensation while others reduce it.
Παναγιώτα Γεωργιάδου, Bahriye Erkaya, Michiko Niwa‐Kawakita…·Umut Şahin
This study shows that Pml loss worsens NEK1-linked ALS, while Pml induction reduces disease symptoms by clearing Nek1t aggregates.