Simone Mosna

This study investigates how TDP-43 phase separation affects its protein interactome and regulation of alternative splicing, showing PS-dependent interactions with RNA regulators.

This study shows phosphorylation of TDP-43's low-complexity domain shifts its self-assembly from macrophase separation to micellization, potentially protecting against pathological aggregation.

This study shows that the disordered NLS-region of TDP-43 is essential for its self-assembly across multiple scales, with a minimal mutation preserving condensation while others reduce it.