Targeting fatty acid synthase suppresses tumor development in NF2/CDKN2A-deficient malignant pleural mesothelioma
Sivasundaram Karnan, Akinobu Ota, Muhammad Nazmul Hasan, Hideki Murakami, Md Lutfur Rahman, Md Wahiduzzaman, Md Towhid Ahmed Shihan, Nushrat Jahan, Lam Quang Vu, Ichiro Hanamura, Akihito Inoko, Miho Riku, Hideaki Ito, Yoshifumi Kaneko, Yinzhi Lin, , Yoshitaka Hosokawa
This study identifies FASN inhibition as a therapeutic strategy for NF2/CDKN2A-deficient MPM, showing reduced tumor growth in xenograft models.
Cell Death and Disease · Feb 28, 2026Peer-reviewedCancer Biology