Chaperonin activity of Plasmodium prefoldin complex is essential to guard proteotoxic stress response and presents a new target for drug discovery
Rumaisha Shoaib, Vikash Kumar, Swati Garg, Monika Saini, Jyoti Kumari, Preeti Maurya, Aashima Gupta, Nutan Gupta, Harshita Singh, Pritee Verma, Ravi Jain, Shreeja Biswas, Ankita Behl, Mohammad Abid, Shailja Singh
This study identifies the Plasmodium prefoldin complex as essential for proteotoxic stress response and demonstrates that biperiden inhibits its function, offering a new drug target for malaria.
bioRxiv · Sep 17, 2022 · PreprintMolecular Biology