Erythrocytic plasma membrane calcium ATPase (PMCA4b) variations mediate redox imbalance to determine artemisinin sensitivity in malaria
Priya Agrohi, Swati Garg, Shreeja Biswas, Preeti Maurya, Vijay Kumar, Bidhan Goswami, Samir Kumar Sil, Mrigendra Pal Singh, Sunil Kumar Chand, Sneh Shalini, O. P. Singh, Gunanidhi Dhangadamajhi, Sivaprakash Ramalingam, Prashant K. Mallick, Shailja Singh
This study shows that host PMCA4b variations affect intraerythrocytic calcium and ROS levels, reducing artemisinin sensitivity in malaria parasites.
bioRxiv · Dec 17, 2024 · PreprintMicrobiology