Live-Cell Imaging in Human Colonic Monolayers Reveals Erk Waves Limit the Stem Cell Compartment to Maintain Epithelial Homeostasis
K. W. Pond, O. Alkhimenok, J. Chakrabarti, Y. Zavros, C. A. Thorne, A. L. Paek
The paper uses live-cell imaging in human colonic organoids to show Erk signaling waves maintain stem cell compartments and tissue homeostasis by restricting stem cell expansion.
bioRxiv · Feb 23, 2022Cell Biology