J. Chakrabarti

Dynamics of aqueous suspension of short Hyaluronic acid chains near DPPC bilayer

This study uses molecular dynamics simulations to investigate the dynamics of short HA chains near a DPPC bilayer, revealing subdiffusive behavior and concentration-dependent diffusion.

Conformational stability and order of Hoogsteen base pair induced by protein binding

The paper uses molecular dynamics simulations to show that protein binding stabilizes and orders Hoogsteen base pairs in DNA, with key roles for sugar-phosphate, sugar-base, and sugar-pucker torsion angles.

Fluctuation dominated ligand binding in molten globule protein

The paper uses molecular dynamics simulations to study ligand binding in the molten globule state of bovine lactalbumin, finding that fluctuation dynamics dominate the binding process.

Genetically Engineered Human Pituitary Corticotroph Tumor Organoids Exhibit Divergent Responses To Glucocorticoid Receptor Modulators

This study uses PitNET organoids to show relacorilant reduces tumor growth and induces apoptosis better than mifepristone, and enhances response to somatostatin analogs.

Conformational fluctuations in molten globule state of α-lactalbumin

The paper studies conformational fluctuations in the molten globule state of α-lactalbumin and finds it behaves similarly to intrinsic disordered proteins.

Effect on the conformations of spike protein of SARS-CoV-2 due to mutation

The paper examines how mutations in SARS-CoV-2 spike protein affect its conformational flexibility and thermodynamics, leading to increased open-state stability in variants of concern.

Live-Cell Imaging in Human Colonic Monolayers Reveals Erk Waves Limit the Stem Cell Compartment to Maintain Epithelial Homeostasis

The paper uses live-cell imaging in human colonic organoids to show Erk signaling waves maintain stem cell compartments and tissue homeostasis by restricting stem cell expansion.