Genetically Engineered Human Pituitary Corticotroph Tumor Organoids Exhibit Divergent Responses To Glucocorticoid Receptor Modulators
S. Mallick, J. Chakrabarti, J. Eschbacher, A. G. Moraitis, A. E. Greenstein, J. Churko, K. W. Pond, A. Livolsi, C. A. Thorne, A. S. Little, K. C. Yuen, Y. Zavros
This study uses PitNET organoids to show relacorilant reduces tumor growth and induces apoptosis better than mifepristone, and enhances response to somatostatin analogs.
bioRxiv · Sep 7, 2022Physiology