Author

O. B. Davis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. C.-N. Ho· 1 shared A. G. Henry· 1 shared C. F. Maher· 1 shared C.-Y. Lim· 1 shared D. Joy· 1 shared E. Y. Wu· 1 shared G. Di Paolo· 1 shared H. R. Shin· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCell Biology

A. C.-N. Ho

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Rab12 regulates LRRK2 activity by promoting its localization to lysosomes

V. V. Bondar, X. Wang, O. B. Davis, M. T. Maloney, M. Agam, M. Y. Chin, A. C.-N. Ho, D. Joy, J. W. Lewcock, G. Di Paolo, R. G. Thorne, Z. K. Sweeney, A. G. Henry

This study identifies Rab12 as a regulator of LRRK2 activity by promoting its localization to lysosomes, leading to increased phosphorylation of Rab10.

bioRxiv · Feb 21, 2023 · PreprintCell Biology

NPC1-mTORC1 signaling Couples Cholesterol Sensing to Organelle Homeostasis and is a Targetable Pathway in Niemann-Pick type C

O. B. Davis, H. R. Shin, C.-Y. Lim, E. Y. Wu, M. Kukurugya, C. F. Maher, R. M. Perera, P. Ordonez, R. Zoncu

This study identifies mTORC1 hyperactivation as a downstream driver of lysosomal dysfunction in NPC, showing that its inhibition can restore proteolysis and mitigate mitochondrial dysfunction.

bioRxiv · Aug 2, 2020Cell Biology