Author

H. R. Shin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:differential expression· 1

Frequent Co-Authors

R. M. Perera· 2 shared R. Zoncu· 2 shared A.-H. Jang· 1 shared C. F. Maher· 1 shared C.-Y. Lim· 1 shared D. W. Dawson· 1 shared E. Y. Wu· 1 shared G. E. Kim· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

R. M. Perera

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Author profile →

3 papers

Recent·Most cited

Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth

S. Gupta, J. A. Yano, H. Htwe Htwe, H. R. Shin, Z. Cakir, T. Ituarte, K. W. Wen, G. E. Kim, R. Zoncu, D. W. Dawson, R. M. Perera

This study identifies Myoferlin as a lysosomal membrane integrity factor in pancreatic cancer, showing its role in lysosome health and tumor growth.

Nature Cell Biology · Mar 8, 2021Peer-reviewedCancer Biology

Engineered Prime Editors with PAM flexibility

J. Kweon, J.-K. Yoon, A.-H. Jang, H. R. Shin, J.-E. See, G. Jang, J.-I. KIM, Y. Kim

This paper describes engineered prime editors that expand target site range by using PAM-flexible Cas9 variants.

bioRxiv · Nov 10, 2020Bioengineering

NPC1-mTORC1 signaling Couples Cholesterol Sensing to Organelle Homeostasis and is a Targetable Pathway in Niemann-Pick type C

O. B. Davis, H. R. Shin, C.-Y. Lim, E. Y. Wu, M. Kukurugya, C. F. Maher, R. M. Perera, P. Ordonez, R. Zoncu

This study identifies mTORC1 hyperactivation as a downstream driver of lysosomal dysfunction in NPC, showing that its inhibition can restore proteolysis and mitigate mitochondrial dysfunction.

bioRxiv · Aug 2, 2020Cell Biology