Author

O. Berninghausen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Assay:cryo-EM· 4 Research Focus:protein folding & dynamics· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:structural biology· 2 Organism:yeast· 2

Frequent Co-Authors

R. Beckmann· 6 shared J. Cheng· 3 shared R. Buschauer· 2 shared T. Becker· 2 shared A. A. Pochopien· 1 shared A. Magoulopoulou· 1 shared A. R. Buskirk· 1 shared B. Beatrix· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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6 shared papersBiochemistry

R. Beckmann

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6 papers

Recent·Most cited

Concurrent remodelling of nucleolar 60S subunit precursors by the Rea1 ATPase and Spb4 RNA helicase

V. Mitterer, M. Thoms, R. Buschauer, O. Berninghausen, E. Hurt, R. Beckmann

This study shows how Rea1 ATPase and Spb4 helicase work together to remodel pre-60S ribosomal particles by restructuring rRNA and removing assembly factors.

bioRxiv · Nov 14, 2022Biochemistry

Clearing of ribosome collisions by the ribosome quality control trigger complex RQT

K. M. Best, K. Ikeuchi, L. Kater, D. M. Best, J. Musial, Y. Matsuo, O. Berninghausen, T. Becker, T. Inada, R. Beckmann

The paper shows RQT clears collided ribosomes by pulling mRNA to trigger destabilizing conformational transitions for subunit dissociation.

bioRxiv · Apr 19, 2022 · PreprintBiochemistry

A distinct assembly pathway of the human 39S late pre-mitoribosome

J. Cheng, O. Berninghausen, R. Beckmann

The paper solves cryo-EM structures of human 39S pre-ribosomes to reveal late assembly intermediates and factors involved in mitoribosome formation.

bioRxiv · Mar 17, 2021Biochemistry

Structure of Gcn1 bound to stalled and colliding 80S ribosomes

A. A. Pochopien, B. Beckert, S. Kasvandik, O. Berninghausen, R. Beckmann, T. Tenson, D. N. Wilson

This study presents a cryo-EM structure of yeast Gcn1 bound to stalled and colliding 80S ribosomes, revealing its interaction with ribosomes and the role of Rbg2/Gir2 in repressing Gcn2.

bioRxiv · Oct 31, 2020Biochemistry

Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts

P. Tesina, L. N. Lessen, R. Buschauer, J. Cheng, C. C.-C. Wu, O. Berninghausen, A. R. Buskirk, T. Becker, R. Beckmann, R. Green

This study identifies molecular mechanisms of translational stalling caused by inhibitory codon pairs and poly(A) tracts using in vitro biochemistry, ribosome profiling, and cryo-EM.

bioRxiv · Sep 4, 2019Biochemistry

Structural and mutational analysis of the ribosome-arresting human XBP1u

V. Shanmuganathan, N. Schiller, A. Magoulopoulou, J. Cheng, K. Braunger, F. Cymer, O. Berninghausen, B. Beatrix, K. Kohno, G. v. Heijne, R. Beckmann

This study presents a cryo-EM structure of XBP1u and shows that only specific mutations in its AP region are optimal for translational arrest.

bioRxiv · Mar 25, 2019Biochemistry