T. Tenson

A history of repeated antibiotic usage leads to microbiota-dependent mucus defects

This study shows that repeated antibiotic use in humans leads to microbiota changes that impair intestinal mucus function in mice.

A role for the S4-domain containing protein YlmH in ribosome-associated quality control in Bacillus subtilis

This study identifies YlmH as a novel RQC factor in B. subtilis, showing it can replace RqcP in polyalanine tail addition and is conserved in bacteria lacking RqcP.

Mechanism of phage sensing and abortion by toxin-antitoxin-chaperone systems

This study identifies and characterizes two Escherichia coli TAC systems that mediate antiphage defense by recognizing phage proteins and modifying mRNA to inhibit translation.

The structural basis of hyperpromiscuity in a core combinatorial network of Type II toxin-antitoxin and related phage defence systems

The paper identifies a core combinatorial network of Type II toxin-antitoxin systems, reveals their structural basis for hyperpromiscuity, and validates new TA systems with functional annotations.

Involvement of the putative metal efflux protein YbeX in ribosomal metabolism

This study identifies YbeX as a factor involved in ribosomal metabolism by maintaining magnesium homeostasis in E. coli.

What is hidden in the darkness? Deep-learning assisted large-scale protein family curation uncovers novel protein families and folds

This work uses deep learning to uncover novel protein families and folds by analyzing sequence and structural data, adding new entries to Pfam and identifying a novel toxin-antitoxin system.

Synthetic oxepanoprolinamide iboxamycin is highly active against human pathogen Listeria monocytogenes

This study shows synthetic iboxamycin is effective against Listeria monocytogenes, overcoming resistance mechanisms, and highlights potential resistance development.

Broad-spectrum mono- and combinational drug therapies for global viral pandemic preparedness

The paper develops scoring systems to predict novel broad-spectrum antivirals and combinations, aiming to improve preparedness for future viral outbreaks.

Active components of commonly prescribed medicines affect influenza A virus-host cell interaction: a pilot study

This study examines how active components of commonly prescribed medicines affect influenza A virus-host cell interactions both in silico and in vitro.

Nafamostat-interferon-alpha combination suppresses SARS-CoV-2 infection by targeting cooperatively host TMPRSS2 in vitro and in vivo

This study combines nafamostat and interferon-alpha to suppress SARS-CoV-2 infection by targeting TMPRSS2 in vitro and in vivo.

Panacea: a hyperpromiscuous antitoxin protein domain for the neutralisation of diverse toxin domains

The paper identifies and validates a hyperpromiscuous antitoxin domain, Panacea, capable of neutralizing diverse toxin domains across microbial and bacteriophage TA systems.

RelA-SpoT Homologue toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis

The paper investigates how four RSH toxins inhibit bacterial growth by pyrophosphorylating tRNA, disrupting protein synthesis and amino acid sensing.

Interferon alpha-based combinations suppress SARS-CoV-2 infection in vitro and in vivo

This study shows that IFNa-based combinations effectively inhibit SARS-CoV-2 infection in vitro and in vivo, with synergistic effects against other viruses.

Structure of Gcn1 bound to stalled and colliding 80S ribosomes

This study presents a cryo-EM structure of yeast Gcn1 bound to stalled and colliding 80S ribosomes, revealing its interaction with ribosomes and the role of Rbg2/Gir2 in repressing Gcn2.

Identification of novel antiviral drug combinations in vitro and tracking their development

This study identifies novel synergistic antiviral drug combinations effective against SARS-CoV-2, echovirus 1, HCV, and HIV-1 in vitro and provides an online resource for their developmental status.

Structural basis for bacterial ribosome quality control

This study identifies RqcH and YabO as factors mediating C-terminal tailing in Bacillus subtilis through cryo-EM structures showing their role in tRNA movement without mRNA or small subunit.

A widespread toxin-antitoxin system exploiting growth control via alarmone signalling

The paper identifies toxin-antitoxin systems in bacteria using alarmone signalling, showing how SASs function as toxins and their antitoxins counteract them.

Dividing subpopulation of Escherichia coli in stationary phase

The paper shows that dynamic cell division and death balance occur in Escherichia coli cultures before mutant populations take over.

Muropeptides Stimulate Growth Resumption from Stationary Phase in Escherichia coli

This study identifies muropeptides as a universal cue for bacterial growth resumption from stationary phase in E. coli and other species.

Critical Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis

This study identifies critical host-virus interaction nodes through network analysis and drug re-purposing, revealing key targets for antiviral therapies.