Collagenesis Orchestrates Mechanoadaptive Homeostasis of Intervertebral Disc
J. He, S. Huang, Y. Li, Y. Wang, P. Yan, O. Hu, P. Lin, H. Jin, J. Zhu, L. Zhang, Y. Liu, Q. Qin, Y. Guo, X. Zheng, Y. Xie, , Y. Gan
The paper identifies a novel mechanoadaptive process in intervertebral discs through collagenesis, revealing TRPV4's role in collagen II synthesis and mechanical stress adaptation.
bioRxiv · Jul 24, 2023 · PreprintPhysiology