Q. Qin

CTAT-LR-fusion: accurate fusion transcript identification from long and short read isoform sequencing at bulk or single cell resolution

CTAT-LR-fusion detects fusion transcripts from long and short read RNA-seq data, improving accuracy in bulk and single cell transcriptomes.

Collagenesis Orchestrates Mechanoadaptive Homeostasis of Intervertebral Disc

The paper identifies a novel mechanoadaptive process in intervertebral discs through collagenesis, revealing TRPV4's role in collagen II synthesis and mechanical stress adaptation.

Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey bee Apis mellifera

This study shows imidacloprid causes developmental delay in honey bee larvae by disrupting molting regulation and nutrient energy metabolism.

CNTNAP4 signaling regulates osteosarcoma disease progression

This study shows that CNTNAP4 signaling promotes osteosarcoma progression, and its deletion reduces tumor growth, angiogenesis, and metastasis.

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

NELL-1 regulates the matrisome to alter osteosarcoma disease progression

This study shows NELL-1 promotes osteosarcoma progression by altering the matrisome, with loss of NELL-1 reducing invasion and improving survival in both human and mouse models.

Molecular mechanisms governing circulating immune cell heterogeneity across different species revealed by single cell sequencing

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.

Screening of cell-virus, cell-cell, gene-gene interactions among kingdoms of life at single cell resolution

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

Viral receptor profiles of masked palm civet revealed by single-cell transcriptomics

The paper uses single-cell transcriptomics to profile viral receptor expression in masked palm civets, identifying potential tissue tropisms for 132 viruses.

NGF-p75 signaling coordinates skeletal cell migration during bone repair

This study identifies NGF-p75 signaling as critical for coordinating skeletal cell migration during bone repair by affecting osteogenic precursor migration and bone healing.

An endoplasmic reticulum (ER) ATPase safeguards ER identity by removing ectopically localized mitochondrial proteins

This study identifies CATP-8 as an ER-localized P5A ATPase that removes mislocalized mitochondrial proteins from the ER, preserving ER identity and function.

CRISPR/Cpf1 mediated genome editing enhances Bombyx mori resistance to BmNPV

This study compares CRISPR/Cpf1 orthologs for genome editing efficiency and antiviral ability in silkworms, finding FnCpf1 more effective than SpCas9 against BmNPV.

Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production

This study shows that ITGB4 in airway epithelial cells reduces CCL17 production, thereby suppressing Th2 responses and allergic inflammation in asthma.

Impact of acetolactate synthase inactivation on 1,3-propanediol fermentation by Klebsiella pneumoniae

This study investigates the effect of acetolactate synthase inactivation on 1,3-propanediol fermentation by Klebsiella pneumoniae, showing increased 1,3-PDO production and altered byproduct formation.