M. Solimena

Locally released somatostatin triggers cAMP and Ca2+ signaling in primary cilia to modulate pancreatic β-cell function

This study shows that somatostatin acting on primary cilia of pancreatic β-cells modulates cAMP and Ca2+ signaling, affecting β-cell function and linking cilia length to type-2 diabetes.

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function

This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.

Structure, interaction, and nervous connectivity of beta cell primary cilia

This study reveals the structural and spatial organization of beta cell primary cilia in mouse and human islets, showing their interactions with neighboring cells and nerves, and their role in islet connectivity.

Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses

This study shows that Coxsackievirus B directly kills pancreatic β-cells and elicits weak CD8+ T-cell responses, suggesting vaccination could prevent type 1 diabetes.

OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

The paper shows OSBP-mediated lipid exchange at ER-secretory granule contacts regulates insulin secretion by controlling cholesterol levels and is influenced by PI(4)P, VAPs, and Sac2.

An open-access volume electron microscopy atlas of whole cells and tissues

The paper presents a 3D electron microscopy atlas of whole cells and tissues with high resolution and large volume, enabling new biological insights.

Insulin mRNA is stored in RNA granules in resting beta cells

The paper identifies RNA-binding proteins interacting with insulin mRNA in resting beta cells and shows glucose-induced remodeling of these interactions.

Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs

This study develops a transgenic pig model with SNAP-tagged insulin to investigate in vivo insulin secretory granule dynamics and turnover.

3D FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse beta cells

The paper provides 3D reconstructions of microtubule networks in primary mouse beta cells and shows their role in insulin secretory granule positioning.

Purification of age-distinct insulin secretory granules through antigen restriction

The paper purifies age-distinct insulin secretory granules from INS-1 cells and identifies age-related changes in their lipid composition and membrane properties.

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a new regulator of insulin secretion

The paper identifies FCHSD2 as a new regulator of insulin secretion by analyzing 3D chromatin interactions at the STARD10 locus in human islets.

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

This study identifies STARD10 as a phosphoinositide binding protein that regulates insulin granule biogenesis in beta-cells by affecting phosphatidylinositol levels and proinsulin processing.

ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor

This study identifies ICA512 RESP18HD as a protein condensing factor that regulates insulin aggregation and fibrillation under different pH conditions.

miR-132 controls mouse pancreatic beta cell proliferation and survival through the Pten/Akt/Foxo3 signaling

This study identifies miR-132 as critical for promoting mouse pancreatic beta cell regeneration through the Pten/Akt/Foxo3 signaling pathway.