Author

A. I. Oqua

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Tomas· 3 shared B. Jones· 2 shared M. Solimena· 2 shared A. Hanyaloglou· 1 shared A. Inoue· 1 shared A. Montoya· 1 shared A. Mueller· 1 shared A. Muller· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

A. Tomas

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3 papers

Recent·Most cited

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function

G. Austin, A. I. Oqua, L. ElEid, M. Zhu, Y. Manchanda, P. Peres, H. Coyle, Y. Poliakova, K. Bouzakri, A. Montoya, D. J. Withers, M. Solimena, B. Jones, S. J. Millership, S. Burgold, , A. Tomas

This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.

bioRxiv · Apr 28, 2024Cell Biology

OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

S. Panagiotou, K.-W. Tan, P. M. Nguyen, A. Mueller, A. I. Oqua, A. Tomas, A. Wendt, L. Eliasson, A. Tengholm, M. Solimena, O. Idevall-Hagren

The paper shows OSBP-mediated lipid exchange at ER-secretory granule contacts regulates insulin secretion by controlling cholesterol levels and is influenced by PI(4)P, VAPs, and Sac2.

bioRxiv · Feb 22, 2023Cell Biology

Agonist binding affinity determines palmitoylation of the glucagon-like peptide-1 receptor and its functional interaction with plasma membrane nanodomains in pancreatic beta cells

T. Buenaventura, W. E. Laughlin, S. Bitsi, T. Burgoyne, Z. Lyu, A. I. Oqua, H. Norman, E. R. McGlone, A. S. Klymchenko, I. R. Correa, A. Walker, A. Inoue, A. Hanyaloglou, G. A. Rutter, S. R. Bloom, , A. Tomas

This study shows that agonist binding affinity affects GLP-1R palmitoylation, nanodomain clustering, and signaling in pancreatic beta cells, influencing insulin secretion.

bioRxiv · Dec 10, 2018Cell Biology