Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infection
C. Illingworth, J. A. Guerra-Assuncao, S. Gregg, O. J. Charles, J. Pang, S. Roy, R. Abdelnabi, J. Neyts, J. Breuer
This study examines the genetic effects of effective and suboptimal dosing of mutagenic drugs on SARS-CoV-2 in hamsters, finding dose-dependent mutational load and no drug resistance.
bioRxiv · Feb 20, 2023Evolutionary Biology