The paper compares two receptor pathways in Arabidopsis root endodermis cells, showing distinct outputs despite similar MPK phosphorylation patterns, suggesting specificity through combinatorial activation and cross-pathway inhibition.

bioRxiv · Jul 3, 2023 · PreprintPlant Biology

Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infection

C. Illingworth, J. A. Guerra-Assuncao, S. Gregg, O. J. Charles, J. Pang, S. Roy, R. Abdelnabi, J. Neyts, J. Breuer

This study examines the genetic effects of effective and suboptimal dosing of mutagenic drugs on SARS-CoV-2 in hamsters, finding dose-dependent mutational load and no drug resistance.

bioRxiv · Feb 20, 2023Evolutionary Biology

Host and transmission route of Enterocytozoon hepatopenaei (EHP) from dragonfly to shrimp

N. Kumar Dewangan, J. Pang, C. Zhao, C. Cao, B. Yin, S. Weng, J. He

This study identifies dragonflies as natural hosts of EHP and confirms horizontal transmission between dragonflies and shrimp.

bioRxiv · Feb 17, 2023 · PreprintMicrobiology

Loss of chromosome Y in primary tumors

M. Qi, J. Pang, I. Mitsiades, A. Lane, E. Rheinbay

The paper analyzes LOY in over 5,000 male tumors from TCGA, showing variation by tumor type and identifying LOY as a potential driver or passenger event with therapeutic implications in uveal melanoma.

bioRxiv · Aug 22, 2022Cancer Biology

Pancreatic Brsk2 amplifies parasympathetic signals to promote type 2 diabetes

R. Xu, K. Wang, Z. Yao, L. Jin, J. Pang, Y. Zhou, K. Wang, D. Liu, Y. Zhang, P. Sun, F. Wang, x. Chang, Y. Li, S. Wang, Y. Zhang, , X. Han

This study shows Brsk2 amplifies parasympathetic signals to promote type 2 diabetes by enhancing β-cell insulin secretion in obese mice and associates human BRSK2 variants with metabolic disorders.

bioRxiv · Aug 5, 2021 · PreprintPathology

Generation of human chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseases

B. X. Ho, J. Pang, Q. H. Phua, L. C. Liew, B. M. Poh, Y. Chen, Y.-H. Loh, O. An, H. H. Yang, V. P. Seshachalam, J. L. Koh, W.-K. Chan, S.-Y. Ng, B.-S. Soh

This study generates human chambered cardiac organoids from pluripotent stem cells to model cardiac hypertrophy and improve cardiovascular disease research.

bioRxiv · May 21, 2021 · PreprintCell Biology

The combined treatment of Molnupiravir and Favipiravir results in a marked potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model

R. Abdelnabi, C. S. Foo, S. J. F. Kaptein, X. Zhang, L. Langendries, L. Vangeel, J. Breuer, J. Pang, R. Williams, V. Vergote, E. Heylen, P. Leyssen, K. Dallmeier, L. Coelmont, D. Jochmans, , J. Neyts

This study shows that combining Molnupiravir and Favipiravir significantly enhances antiviral efficacy against SARS-CoV-2 in hamsters, reducing viral titers by 4.5 log10 and eliminating detectable virus in 60% of treated animals.

bioRxiv · Dec 10, 2020Microbiology

Pancreas-specific miR-216a regulates proliferation and endocrine and exocrine cell function in vivo

S. Erener, C. E. Ellis, A. Ramzy, M. M. Glavas, S. O'Dwyer, S. Pereira, T. Wang, J. Pang, J. E. Bruin, M. J. Riedel, R. J. Baker, T. D. Webber, J. L. Kopp, S. Herzig, T. J. Kieffer

This study identifies miR-216a as a pancreas-specific miRNA that regulates cell proliferation and function in both endocrine and exocrine cells, with implications for diabetes and pancreatic cancer.

bioRxiv · Oct 7, 2019 · PreprintPhysiology

HDL-AuNPs-BMS nanoparticle conjugates as molecularly targeted therapy for leukemia

N. Shen, F. Yan, J. Pang, Z. Gao, A. Al-Kali, C. L. Haynes, M. R. Litzow, S. Liu

This paper develops HDL-AuNPs-BMS conjugates for leukemia treatment, showing enhanced drug delivery and epigenetic modulation in AML cells and mice.

bioRxiv · Jan 20, 2018Cancer Biology