The PMK-3 (p38) Mitochondrial Retrograde Response Functions in Intestinal Cells to Extend Life via the ESCRT Machinery.
O. Radetskaya, R. K. Lane, T. Friedman, A. Garrett, M. Nguyen, M. B. Borror, J. Russell, S. L. Rea
This study identifies PMK-3 as a key regulator of life extension in C. elegans following mitochondrial ETC disruption, showing its reliance on ESCRT machinery for cellular signaling.
bioRxiv · Oct 22, 2019 · PreprintPathology