T. Friedman

BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved antitumor activity

This paper evaluates BOXR1030, a CAR T cell therapy co-expressing GPC3-targeted CAR and GOT2, showing enhanced T cell metabolism and improved antitumor activity in preclinical models.

Reovirus sensitizes microsatellite stable colorectal cancer to anti-PD-1 treatment via cross-talk in innate and adaptive immune systems

This study shows that reovirus enhances anti-PD-1 treatment effectiveness in microsatellite stable colorectal cancer by modulating innate and adaptive immune responses.

The PMK-3 (p38) Mitochondrial Retrograde Response Functions in Intestinal Cells to Extend Life via the ESCRT Machinery.

This study identifies PMK-3 as a key regulator of life extension in C. elegans following mitochondrial ETC disruption, showing its reliance on ESCRT machinery for cellular signaling.