LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells
O. Susanto, Y. Koh, N. Morrice, S. Tumanov, P. Thomason, M. Neilson, L. Tweedy, A. Muinonen-Martin, J. Kamphorst, G. Mackay, R. H. Insall
The paper shows that LPP3 is essential for melanoma cells to break down LPA, enabling self-generated chemotaxis and invasion.
bioRxiv · Jun 21, 2017Cancer Biology