Author

N. Morrice

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

R. Gourlay· 2 shared A. J. Whitworth· 1 shared A. Karapetsas· 1 shared A. Knebel· 1 shared A. Muinonen-Martin· 1 shared A. Shaw· 1 shared A. Terriente-Felix· 1 shared A. U. Malik· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

R. Gourlay

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Regulation of Human PINK1 ubiquitin kinase by Serine167, Serine228 and Cysteine412 phosphorylation

A. Waddell, H. Ojha, S. Agarwal, C. Clarke, A. Terriente-Felix, H. Zhou, P. Kakade, A. Knebel, A. Shaw, R. Gourlay, J. Varghese, R. Soares, R. Toth, T. Macartney, P. Eyers, , M. Muqit

This study identifies phosphorylation sites in hPINK1 that regulate its activation and ubiquitin interaction, revealing a novel inhibitory mechanism involving pCys412.

bioRxiv · Mar 31, 2023 · PreprintBiochemistry

Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice.

D. Thompson, S. Mahmood, N. Morrice, S. Kamli-Salino, R. Dekeryte, P. Hoffmann, M. K. Doherty, P. D. Whitfield, M. Delibegovic, N. Mody

This study shows that fenretinide reduces obesity and fatty liver but increases ceramides via Smpd3, worsening atherosclerosis in LDLR-/- mice.

bioRxiv · Jul 22, 2022Physiology

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain

A. U. Malik, A. Karapetsas, R. S. Nirujogi, D. Chatterjee, T. K. Phung, M. Wightman, R. Gourlay, N. Morrice, S. Mathea, S. Knapp, D. R. Alessi

This study identifies that PKC isoforms activate LRRK1 by phosphorylating specific residues in the CORB GTPase domain, enhancing kinase activity.

bioRxiv · Jun 9, 2022Biochemistry

Accelerated Protein Biomarker Discovery from FFPE tissue samples using Single-shot, Short Gradient Microflow SWATH MS

R. Sun, C. Hunter, C. Chen, G. Weigang, N. Morrice, S. Liang, Y. c. Hui, Q. Zhang, X. Cai, X. Yu, L. Chen, S. Dai, Z. Luan, R. Aebersold, Y. Zhu, T. Guo

This paper introduces an accelerated SWATH MS method for protein biomarker discovery in FFPE tissues, showing reduced instrument time and batch effects while maintaining good protein quantification and clinical separation.

bioRxiv · Oct 7, 2019Cancer Biology

LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells

O. Susanto, Y. Koh, N. Morrice, S. Tumanov, P. Thomason, M. Neilson, L. Tweedy, A. Muinonen-Martin, J. Kamphorst, G. Mackay, R. H. Insall

The paper shows that LPP3 is essential for melanoma cells to break down LPA, enabling self-generated chemotaxis and invasion.

bioRxiv · Jun 21, 2017Cancer Biology