Author

M. Lässig

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Evolutionary Biology· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 6 Research Focus:host-pathogen & immune response· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Organism:virus· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

D. Ruchnewitz· 2 shared M. Meijers· 2 shared A. Konrad· 1 shared D. Güleresi· 1 shared D. I. Andersson· 1 shared F. Pinheiro· 1 shared I. Gordo· 1 shared J. Eberhardt· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiophysics

D. Ruchnewitz

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Concepts and methods for predicting viral evolution

M. Meijers, D. Ruchnewitz, J. Eberhardt, M. Karmakar, M. Łuksza, M. Lässig

This paper develops methods to predict viral evolution using integrated data on sequences, epidemiology, antigenicity, and phenotypes, providing vaccine strain selection insights.

bioRxiv · Mar 19, 2024 · PreprintBiophysics

Non-equilibrium antigen recognition in acute infections

R. Moran-Tovar, M. Lässig

This paper models B-cell antigen recognition during acute infections, showing it follows a generalized Luria-Delbruck process with power-law statistics and highlights the impact of aging on immune response.

bioRxiv · Apr 5, 2023 · PreprintBiophysics

Vaccination shapes evolutionary trajectories of SARS-CoV-2

M. Meijers, D. Ruchnewitz, M. Luksza, M. Lässig

This study shows vaccination influences SARS-CoV-2 antigenic evolution by analyzing sequence data, epidemiology, and neutralization assays to model evolutionary dynamics.

bioRxiv · Jul 19, 2022 · PreprintBiophysics

Two modes of evolution shape bacterial strain diversity in the gut for thousands of generations

N. Frazao, A. Konrad, D. Güleresi, M. Lässig, I. Gordo

This study shows that two evolutionary modes shape bacterial strain diversity in the gut over thousands of generations, with diversifying selection leading to ecotype coexistence and directional selection causing selective sweeps.

bioRxiv · Jan 11, 2022Evolutionary Biology

Adaptive ratchets and the evolution of molecular complexity

T. Röschinger, R. Moran Tovar, S. Pompei, M. Lässig

This study shows how molecular recognition sites can evolve to complex states by adapting to moving targets, increasing code length and reducing coding density through an adaptive ratchet mechanism.

bioRxiv · Nov 18, 2021Biophysics

Predicting trajectories and mechanisms of antibiotic resistance evolution

F. Pinheiro, O. Warsi, D. I. Andersson, M. Lässig

The paper develops a fitness model to predict antibiotic resistance evolution by linking metabolic effects to growth rates and resistance levels in E. coli.

bioRxiv · Jul 2, 2020 · PreprintEvolutionary Biology

Eco-evolutionary control of pathogens

M. Lässig, V. Mustonen

The paper develops a fitness model to analyze eco-evolutionary control of pathogens, showing how control strategies depend on mutation rates and population size.

bioRxiv · Nov 29, 2019Evolutionary Biology